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BioMed Research International
Volume 2014, Article ID 527042, 11 pages
Research Article

The Cytotoxicity of Benzaldehyde Nitrogen Mustard-2-Pyridine Carboxylic Acid Hydrazone Being Involved in Topoisomerase IIα Inhibition

1Department of Molecular Biology & Biochemistry, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, Henan 453003, China
2Clinical Skill Training Center, Xinxiang Medical University, Xinxiang, Henan 453003, China

Received 17 February 2014; Accepted 12 May 2014; Published 5 June 2014

Academic Editor: Bruno C. Cavalcanti

Copyright © 2014 Yun Fu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Krzysztof Z. Łączkowski, Joanna Wietrzyk, Berta Fernández, Agata Paneth, Konrad Misiura, Marta Świtalska, Angelika Baranowska-Łączkowska, and Tomasz Plech, “Synthesis and In Vitro antiproliferative activity of Thiazole-Based nitrogen mustards: The hydrogen bonding interaction between model systems and nucleobases,” Anti-Cancer Agents in Medicinal Chemistry, vol. 14, no. 9, pp. 1271–1281, 2014. View at Publisher · View at Google Scholar
  • Yingli Yang, Tengfei Huang, Sufeng Zhou, Yun Fu, Youxun Liu, Yanbin Yuan, Qiongqing Zhang, Shaoshan Li, and Changzheng Li, “Antitumor activity of a 2-pyridinecarboxaldehyde 2-pyridinecarboxylic acid hydrazone copper complex and the related mechanism,” Oncology Reports, vol. 34, no. 3, pp. 1311–1318, 2015. View at Publisher · View at Google Scholar
  • Tengfei Huang, Cuiping Li, Xingzhi Sun, Zhenfu Zhu, Yun Fu, Youxun Liu, Yanbin Yuan, Shaoshan Li, and Changzheng Li, “The antitumor mechanism of di-2-pyridylketone 2-pyridine carboxylic acid hydrazone and its copper complex in ROS generation and topoisomerase inhibiti,” International Journal Of Oncology, vol. 47, no. 5, pp. 1854–1862, 2015. View at Publisher · View at Google Scholar
  • Navidshad, and Royan, “Ligands and regulatory modes of peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in avians,” Critical Reviews in Eukaryotic Gene Expression, vol. 25, no. 4, pp. 287–292, 2015. View at Publisher · View at Google Scholar
  • Violina T. Angelova, Nikolay G. Vassilev, Boryana Nikolova-Mladenova, Jasmina Vitas, Radomir Malbaša, Georgi Momekov, Mirjana Djukic, and Luciano Saso, “Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety,” Medicinal Chemistry Research, 2016. View at Publisher · View at Google Scholar
  • Ming-Yan Yang, Jian-Quan Weng, Xing-Hai Liu, Guo-Xiang Sun, Yan-Xia Shi, Zhi-Wen Zhai, Cheng-Xia Tan, and Bao-Ju Li, “Synthesis, crystal structure and biological activity of (E)-3-chloro-2-(2-(2-methylbenzylidene)-hydrazinyl)pyridine,” Jiegou Huaxue, vol. 35, no. 4, pp. 640–644, 2016. View at Publisher · View at Google Scholar
  • Yinli Yang, Cuiping Li, Yun Fu, Youxun Liu, Yu Zhang, Yanfang Zhang, Pingxin Zhou, Yanbin Yuan, Sufeng Zhou, Shaoshan Li, and Changzheng Li, “Redox cycling of a copper complex with benzaldehyde nitrogen mustard-2-pyridine carboxylic acid hydrazone contributes to its enhanced antitumor activi,” Oncology Reports, vol. 35, no. 3, pp. 1636–1644, 2016. View at Publisher · View at Google Scholar