The Cytotoxicity of Benzaldehyde Nitrogen Mustard-2-Pyridine Carboxylic Acid Hydrazone Being Involved in Topoisomerase IIα Inhibition
Figure 7
Topoisomerase II inhibition of BNMPH. (a) The docked BNMPH in human topoisomerase II-DNA complex. (b) Comparison of BNMPH and etoposide in topoisomerase II complex. (c) Human topoisomerase IIα inhibition of BNMPH. The concentration is used as indicated. At 50 μM BNMPH almost blocked the topoisomerase catalyzed DNA relaxation.
