rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population

Table 3

Stratified analyses of rs744166 genotypes between GC cases and controls.

Variables	rs744166		𝑃 value
	TT	TC+CC
Age (years)
<60
Cases/controls	48/61	58/101
ORadj (95% CI)^a	1.00	0.64 (0.37–1.13)	0.127
≥60
Cases/controls	53/46	50/86
ORadj (95% CI)^a	1.00	0.49 (0.26–0.90)	0.021
Sex
Male
Cases/controls	77/73	81/128
ORadj (95% CI)^a	1.00	0.54 (0.32–0.88)	0.014
Female
Cases/controls	24/34	27/59
ORadj (95% CI)^a	1.00	0.63 (0.28–1.40)	0.254
Smoking status^b
Never
Cases/controls	32/58	39/96
ORadj (95% CI)^a	1.00	0.56 (0.29–1.07)	0.081
Ever
Cases/controls	68/48	69/91
ORadj (95% CI)^a	1.00	0.54 (0.32–0.93)	0.026
Alcohol consumption
Nondrinkers
Cases/controls	39/69	46/103
ORadj (95% CI)^a	1.00	0.73 (0.40–1.31)	0.288
Drinkers
Cases/controls	62/38	62/84
ORadj (95% CI)^a	1.00	0.38 (0.21–0.70)	0.002
Family history of cancer^bc
No
Cases/controls	76/102	81/178
ORadj (95% CI)^a	1.00	0.55 (0.36–0.85)	0.007
Yes
Cases/controls	22/4	25/8
ORadj (95% CI)^a	1.00	0.50 (0.11–2.28)	0.371

OR: odds ratio; CI: confidence interval.
aAdjusted for age, sex, smoking, drinking, BMI, and family history of cancer.
bMissing data: smoking: 2; family history of cancer: 7.
cFamily history of cancer: gastric, esophageal, liver, colorectal, and other cancers.