Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population: Exclusion of Ineligible Candidates for Adjuvant Chemotherapy
Table 1
Predictive factors for identifying patients ineligible to receive full dose of cisplatin-based adjuvant chemotherapy#.
Postoperative eGFR (mL/min/1.73 m2)
Univariate analysis
Multivariate analysis
All
≥60
<60
Chi-square
value
OR
95% CI
value
All, number (%)
353 (100)
160 (45.3)
193 (54.7)
Gender, number (%)
0.004
0.516
Male
167 (47.3)
76 (47.5)
91 (47.2)
Female
186 (52.7)
84 (52.5)
102 (52.8)
Age∧, number (%)
10.966
0.001*
1.007
1.002–1.012
0.002*
<70
200 (56.7)
106 (66.3)
94 (48.7)
≥70
153 (43.3)
54 (33.8)
99 (51.3)
Preoperative eGFR (mL/min/1.73 m2)∧, number (%)
8.235
0.003*
0.993
0.991–0.997
<0.001*
<90
87 (24.6)
51 (31.9)
36 (18.7)
≥90
266 (75.4)
109 (68.1)
157 (81.3)
Previous or concomitant BT, number (%)
0.145
0.417
No
313 (88.7)
143 (89.4)
170 (88.1)
Yes
40 (11.3)
17 (10.6)
23 (11.9)
Side, number (%)
0.533
0.267
Left
173 (49.0)
75 (46.9)
98 (50.8)
Right
180 (51.0)
85 (53.1)
95 (49.2)
Location, number (%)
6.513
0.007*
1.071
0.955–1.202
0.240
Ureter
144 (40.8)
77 (48.1)
67 (34.7)
Pelvis
209 (59.2)
83 (51.9)
126 (65.3)
Hydronephrosis, number (%)
22.657
<0.001*
0.801
0.714–0.899
<0.001*
No
188 (53.3)
63 (39.4)
125 (64.8)
Yes
165 (46.7)
97 (60.6)
68 (35.2)
Multifocality, number (%)
7.038
0.006*
0.876
0.771–0.996
0.044*
No
294 (83.3)
124 (77.5)
170 (88.1)
Yes
59 (16.7)
36 (22.5)
23 (11.9)
DM, number (%)
0.980
0.200
No
297 (84.1)
138 (86.3)
159 (82.4)
Yes
56 (15.9)
22 (13.8)
34 (17.6)
Hypertension, number (%)
2.931
0.055
No
228 (64.6)
111 (69.4)
117 (60.6)
Yes
125 (35.4)
49 (30.6)
76 (39.4)
Smoking, number (%)
2.853
0.060
No
281 (79.6)
121 (75.6)
160 (82.9)
Yes
72 (20.4)
39 (24.4)
33 (17.1)
Tumor size (cm)∧, number (%)
10.514
0.001*
0.962
0.942–0.983
<0.001*
<3
190 (53.8)
71 (44.4)
119 (61.7)
≥3
163 (46.2)
89 (55.6)
74 (38.3)
Architecture, number (%)
11.830
<0.001*
Papillary
268 (75.9)
109 (68.1)
159 (82.4)
Sessile
80 (22.7)
50 (31.3)
30 (15.5)
Stage, number (%)
10.873
0.001*
Ta/T1/T2
233 (66.0)
91 (56.9)
142 (73.6)
T3/T4
120 (34.0)
69 (43.1)
51 (26.4)
Grade, number (%)
2.829
0.058
G1-2
209 (59.2)
87 (54.4)
122 (63.2)
G3
144 (40.8)
73 (45.6)
71 (36.8)
Tumor necrosis, number (%)
2.766
0.069
No
319 (30.4)
140 (87.5)
179 (92.7)
Yes
34 (9.6)
20 (12.5)
14 (7.3)
CIS, number (%)
0.389
0.374
Absent
342 (96.9)
154 (96.3)
188 (97.4)
Present
11 (3.1)
6 (3.8)
5 (2.6)
Statistically significant.
#Only patients with preoperative eGFR ≥ 60 mL/min/1.73 m2 were included. ∧Initially calculated as binary variables in univariate analysis and used as linear variable in multivariate analysis. OR: odds ratio; CI: confidence interval; eGFR: estimated glomerular filtration rate; BT: bladder tumor; DM: diabetes mellitus; CIS: carcinoma in situ.
