Alteration of Basilar Artery Rho-Kinase and Soluble Guanylyl Cyclase Protein Expression in a Rat Model of Cerebral Vasospasm following Subarachnoid Hemorrhage
Figure 1
Effect of CGS 26303 on plasma ET-1 levels (upper panel) and cross section of basilar artery (lower panel). CGS 26303 was administered at 1 (prevention protocol, P) or 24 (reversal protocol, R) hr after the induction of SAH. Plasma levels of ET-1 were measured by ELISA. Data are mean ± SEM (/group). versus SAH. N: normal control; V: vehicle group. No statistically significant difference was found between the SAH and vehicle groups. The cross sections in the SAH+CGS 26303 group were obtained from animals that underwent the prevention protocol. The arrowheads show the endothelial layer and basal lamina. Scale bars in the first and second rows of the micrograms represent 5 and 0.25 μm, respectively.
