Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids
Figure 1
(a) Induction of acid-reflux esophagitis in rats. Under ether anesthesia, the abdomen was incised, and both the pylorus and junction between the corpus and forestomach were ligated. Three or four hours later, animals were killed by an overdose of ether, and the esophagus was removed, opened, and examined for hemorrhagic lesions. (b) Time-course changes in the development of acid-reflux esophagitis in rats. Under ether anesthesia, both the pylorus and forestomach were ligated, and the esophageal mucosa was examined 2~5 h later. Data were presented as the mean ± SE for 4 rats. (c) Gross appearance of esophageal lesions observed at 2, 3, 4, and 5 h after the ligation (from [14, 15] after modifications).
