Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids
Figure 2
Effects of cimetidine, omeprazole, pepstatin (a), and pepsin (b) on acid-reflux esophagitis in rats. Under ether anesthesia, both the pylorus and forestomach were ligated, and the esophageal mucosa was examined 4 h later. Cimetidine (100 mg/kg) and omeprazole (10 mg/kg) were given i.d. immediately after the ligation, while pepstatin (0.1–0.6 mg/kg) and porcine pepsin (5 mg/kg) were given i.g. immediately after the ligation. Data were presented as the mean ± SE for 4~6 rats. *Significantly different from the control, at (from [14, 15] after modifications).
