Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids

Figure 4

Effects of PGE₂ on acid-reflux esophagitis (a) and its attenuation by ONO-AE-829, an EP1 antagonist (b), in rats. Esophagitis was induced by ligation of both the pylorus and forestomach, and animals were killed 4 h later. PGE₂ (0.1~1 mg/kg) was given i.v. 10 min before the double ligation, while ONO-AE-829 (30 mg/kg) was given s.c. 30 min before the administration of PGE₂. Data are presented as the mean ± SE for 4~8 rats. Significant difference at 𝑃<0.05; *from the control; ^#from PGE₂ alone (from [16] after modifications).

(a)

(b)