Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids
Figure 7
Effects of L-glutamine and L-alanine on acid-reflux esophagitis in rats. Under ether anesthesia, both the pylorus and forestomach were ligated, and the esophageal mucosa was examined 3 h later. L-glutamine (250–1500 mg/kg) and L-alanine (250 and 500 mg/kg) were given i.g. immediately after the ligation. Data are presented as the mean ± SE for 5~6 rats. *Significantly different from the corresponding control at . (b) Macroscopic appearance of esophageal lesions induced by ligation of both the pylorus and forestomach for 3 h. L-glutamine (1500 mg/kg) was given i.g. immediately after the ligation. Note that L-glutamine apparently aggravated the severity of hemorrhagic esophageal lesions (from [15, 17] after modifications).
