Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids
Figure 8
Effects of L- or D-arginine and glycine on acid-reflux esophagitis in rats. Under ether anesthesia, both the pylorus and forestomach were ligated, and the esophageal mucosa was examined 4 h later. L-arginine (100 and 250 mg/kg), D-arginine (250 mg/kg), or glycine (250–750 mg/kg) was given i.g. immediately after the ligation. Data are presented as the for 5~7 rats. *Significantly different from the control, at . (b) Macroscopic appearance of esophageal lesions induced by the dual ligation for 3 h. Glycine (750 mg/kg) was given i.g. immediately after the ligation. Note that glycine completely inhibited the development of hemorrhagic esophageal lesions (from [17] after modifications).
