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BioMed Research International
Volume 2014, Article ID 535929, 8 pages
Research Article

An Ex Vivo Model in Human Femoral Heads for Histopathological Study and Resonance Frequency Analysis of Dental Implant Primary Stability

1Department of Traumatology and Orthopedic Surgery, “San Cecilio” Clinical Hospital, University of Granada, Spain
2Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
3Oral Surgery and Implant Dentistry Department, School of Dentistry, University of Granada, Granada, Spain
4Department of Experimental Psychology, School of Psychology, University of Granada, Granada, Spain
5Department of Periodontics, School of Dentistry, University of Granada, Granada, Spain
6Department of Pathology, School of Medicine and Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, Granada, Spain
7Departamento de Anatomía Patológica, Facultad de Medicina, 18012 Granada, Spain

Received 21 January 2014; Revised 12 May 2014; Accepted 19 May 2014; Published 4 June 2014

Academic Editor: Konstantinos Michalakis

Copyright © 2014 Pedro Hernández-Cortés et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. This study was designed to explore relationships of resonance frequency analysis (RFA)—assessed implant stability (ISQ values) with bone morphometric parameters and bone quality in an ex vivo model of dental implants placed in human femoral heads and to evaluate the usefulness of this model for dental implant studies. Material and Methods. This ex vivo study included femoral heads from 17 patients undergoing surgery for femoral neck fracture due to osteoporosis (OP) () or for total prosthesis joint replacement due to severe hip osteoarthrosis (OA) (). Sixty  mm Dentsply Astra implants were placed, followed by RFA. CD44 immunohistochemical analysis for osteocytes was also carried out. Results. As expected, the analysis yielded significant effects of femoral head type (OA versus OA) (), but not of the implants () or of the interaction of the two factors (). Bonferroni post hoc comparisons showed a lower mean ISQ for implants in decalcified () heads than in fresh () or fixated () heads (both ). The ISQ score (fresh) was significantly higher for those in OA () versus OP () heads. However, mixed linear analysis showed no significant association between ISQ scores and morphologic or histomorphometric results ( in all cases), and no significant differences in ISQ values were found as a function of the length or area of the cortical layer (both ). Conclusion. Although RFA-determined ISQ values are not correlated with morphometric parameters, they can discriminate bone quality (OP versus OA). This ex vivo model is useful for dental implant studies.