Insulin Preconditioning Elevates p-Akt and Cardiac Contractility after Reperfusion in the Isolated Ischemic Rat Heart

Figure 4

Time-course changes of LV dP/dt max before and after ischemia in the three groups ( in each group). The data are presented as means ± SD. versus Control; versus Post-Ins. In Pre-Ins, LV dP/dt max increased after administration of insulin prior to ischemia (PC ) compared to both Post-Ins and Control. After reperfusion, dP/dt max in Pre-Ins was elevated, compared with Post-Ins at 10 minutes after reperfusion (Rep ) and Control at all-time points (Rep , , , and ). dP/dt max (mmHg/sec): maximum of left ventricular derivative of pressure development.