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BioMed Research International
Volume 2014, Article ID 536591, 8 pages
Research Article

Computational Analysis of mRNA Expression Profiles Identifies the ITG Family and PIK3R3 as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration

1Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan
2Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
3Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan
4Cathay General Hospital SiJhih, New Taipei 221, Taiwan
5School of Medicine, Fu-Jen Catholic University, New Taipei 242, Taiwan
6School of Medicine, Taipei Medical University, Taipei 110, Taiwan
7Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
8Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
9Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan
10Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, Taipei 116, Taiwan
11Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan

Received 26 November 2013; Accepted 18 March 2014; Published 6 May 2014

Academic Editor: Dongquan Shi

Copyright © 2014 Sukhontip Klahan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (Her2/neu). TNBC has worse clinical outcomes than other breast cancer subtypes. However, the key molecules and mechanisms of TNBC migration remain unclear. In this study, we compared two normalized microarray datasets from GEO database between Asian (GSE33926) and non-Asian populations (GSE46581) to determine the molecules and common pathways in TNBC migration. We demonstrated that 16 genes in non-Asian samples and 9 genes in Asian samples are related to TNBC migration. In addition, our analytic results showed that 4 genes, PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton. Our results indicated potential genes that link to TNBC migration. This study may help identify novel therapeutic targets for drug development in cancer therapy.