NMR-Based Metabolomic Profiling of Overweight Adolescents: An Elucidation of the Effects of Inter-/Intraindividual Differences, Gender, and Pubertal Development
Figure 1
Intrasubject variation in the urine and plasma metabolome of adolescents over a 12-week interval: (a) PCA score plot of urine samples from boys (PC1 explains 28.3% and PC2 explains 16.4% of the variation); (b) PCA score plot of plasma samples from boys (PC1 explains 64.3% and PC2 explains 14.4% of the variation); (c) PCA score plot of urine samples from girls (PC1 explains 24.3% of the variation and PC2 explains 10.2% of the variation); (d) PCA score plot of plasma samples from girls (PC1 explains 55.7% and PC2 explains 11.6% of the variation); (e) PC1 loadings of urine samples; (f) PC1 loadings of plasma samples. The same subject is indicated by the same color in PCA score plots and the arrow points from week 0 to week 12. Assignments: 1: creatinine (3.04 and 4.05 ppm); 2: urea (5.50–6.10 ppm); 3: hippurate (3.96, 7.54, and 7.82 ppm); 4: lipids; 5: glucose.
