Pharmacological Treatments in Gambling Disorder: A Qualitative Review

Table 2

Opioid antagonists in gambling disorder.

Study	Drug tested and mean-range dosage	Study design	Study group and duration	Findings
Opioid antagonists in GD
Kim et al. 2001 [15]	Naltrexone; mean dose 188 mg/day	Double-blind; placebo-controlled	89 patients; for 12 weeks	Naltrexone is significantly superior to placebo
Grant et al. 2008 [29]	Naltrexone; 50–150 mg/day	Double-blind; placebo-controlled	77 patients; for 18 weeks	Naltrexone is significantly superior to placebo
Toneatto et al. 2009 [30]	Naltrexone; mean dose 59 mg/day	Double-blind; placebo-controlled	52 patients; for 11 weeks	Naltrexone is not significantly superior to placebo
Grant et al. 2006 [16]	Nalmefene; 25–100 mg/day	Double-blind; placebo-controlled	207 patients; for 16 weeks	Nalmefene is significantly superior to placebo
Grant et al. 2010 [33]	Nalmefene; 20–40 mg/day	Single-blind; for 1 week with  placebo; Double-blind; placebo-controlled; for 15 weeks	233 patients; for 16 weeks	Nalmefene 40 mg/day is significantly superior to placebo