Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension: A Case-Control Study

Table 2

Distributions of allele frequencies in cases and controls stratified gender wise.

Gene	Allele	Minor allele	Freq. minor allele case	Freq. minor allele control	𝜒^2	OR	𝑃 value
AGT M235T	M/T	M	0.254	0.327	5.527	0.699 (0.518–0.943)	𝟎.𝟎𝟏𝟖^∗
Female			0.226	0.358	7.797	0.522 (0.330–0.826)	𝟎.𝟎𝟎𝟓^∗
Male			0.280	0.308	0.443	0.874 (0.588–1.299)	0.506
ACE I/D	I/D	I	0.398	0.462	3.524	0.770 (0.586–1.012)	0.060
Female			0.441	0.420	0.169	1.091 (0.719–1.656)	0.681
Male			0.357	0.489	8.265	0.584 (0.404–0.844)	𝟎.𝟎𝟎𝟒^∗
ACE G2350A	G/A	A	0.173	0.164	0.136	1.070 (0.746–1.535)	0.713
Female			0.172	0.210	0.866	0.780 (0.461–1.318)	0.352
Male			0.174	0.135	1.444	1.357 (0.824–2.236)	0.229
AGTR1 A1166C	A/C	C	0.384	0.401	0.244	0.933 (0.708–1.230)	0.622
Female			0.363	0.414	0.985	0.807 (0.529–1.233)	0.321
Male			0.404	0.392	0.064	1.049 (0.726–1.515)	0.800

𝜒²: Chi-square with 1 degree of freedom; OR: odds ratio; ^∗𝑃<0.05: statically significant (alpha value 0.05/4).