The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children
Table 2
Association of the 15 SNPs in INSIG-SCAP-SREBP pathway with obesity.
Nearest gene
Effect allele
Obese vs nonobese
OR
95% CI
Nominal valuea
rs2721
INSIG1
T
0.94
0.81
1.09
0.394
rs13223383
INSIG1
T
0.90
0.78
1.04
0.164
rs7566605
INSIG2
C
1.04
0.91
1.20
0.547
rs10185316
INSIG2
G
1.04
0.87
1.25
0.665
rs13428113
INSIG2
C
0.98
0.86
1.11
0.714
rs17047757
INSIG2
G
1.04
0.89
1.21
0.622
rs9308762
INSIG2
T
1.03
0.90
1.17
0.710
rs12487736
SCAP
G
1.15
1.01
1.32
0.039
rs12490383
SCAP
C
1.17
1.02
1.33
0.026
rs2297508
SREBP1
C
1.02
0.85
1.23
0.813
rs60282872
SREBP1
DEL
0.88
0.67
1.16
0.367
rs7287010
SREBP2
T
1.03
0.89
1.18
0.706
rs1883205
SREBP2
T
0.92
0.80
1.05
0.222
rs133290
SREBP2
C
0.98
0.85
1.14
0.825
rs2228314
SREBP2
C
1.17
1.00
1.37
0.051
Adjusted for sex, age, age square, and study population. INSIG1, insulin induced gene 1; INSIG2, insulin induced gene 2; SCAP, SREBP cleavage-activating protein gene; SREBP1, sterol regulatory element binding protein 1 gene; SREBP2, sterol regulatory element binding protein 2 gene.
