Effects of Various Antiepileptics Used to Alleviate Neuropathic Pain on Compound Action Potential in Frog Sciatic Nerves: Comparison with Those of Local Anesthetics
Figure 2
Effects of carbamazepine (CBZ) and oxcarbazepine (OXC) on CAPs recorded from frog sciatic nerve fibers. ((a)(A)), ((b)(A)) The chemical structures of CBZ ((a)(A)) and OXC ((b)(A)). ((a)(B)), ((b)(B)) Average time course of changes in CAP peak amplitude following exposure to CBZ ((a)(B)) or OXC ((b)(B)) for 20 min, relative to those before the soaking (each point: ). ((a)(C)), ((b)(C)) The peak amplitudes of CAPs recorded from sciatic nerve fibers treated with CBZ (((a)(C)); each point: –9) or OXC (((b)(C)); ) at various concentrations for 20 min, relative to control, which were plotted against its concentration. The concentration-response curve in ((a)(C)) was drawn according to the Hill equation (IC50 0.50 mM, ). ((a)(D)), ((b)(D)) Recordings of CAPs before and at 20 min after exposure to CBZ ((a)(D)) or OXC ((b)(D)) at 0.7 mM. Solid line in the graph of ((b)(C)) was arbitrarily drawn.
