Evaluation of Anticonvulsant, Sedative, Anxiolytic, and Phytochemical Profile of the Methanol Extract from the Aerial Parts of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke

Table 1

Effect of methanol extract of Swertia corymbosa (SCMeOH) on pentylenetetrazole induced seizure.

Treatment (mg/kg)	Latency of tonic convulsion (sec)	Duration of tonic convulsion (s)	Mortality (% death)	% protection
Control	100.20 ± 3.34	446.10 ± 5.19	6/6 (100)	0.0
Diazepam (5 mg/kg, i.p.)	478.34 ± 6.07**	126.69 ± 1.93**	0/6 (0.0)	100
SCMeOH 125	141.43 ± 1.98	216.29 ± 1.23	4/6 (66.66)	33.33
SCMeOH 250	298.16 ± 4.45*	189.19 ± 1.72*	3/6 (50.00)	50.0
SCMeOH 500	416.42 ± 6.14**	137.11 ± 2.61**	0/6 (16.66)	100

Control (vehicle)—distilled water.
The data represent the mean ± SD (𝑛=6). *𝑃<0.01, **𝑃<0.001 significantly different compared to PTZ induced seizure control.