Evaluation of Anticonvulsant, Sedative, Anxiolytic, and Phytochemical Profile of the Methanol Extract from the Aerial Parts of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke

Table 2

Effect of methanol extract of Swertia corymbosa (SCMeOH) on INH induced seizure in mice.

Treatment (mg/kg)	Latency of tonic convulsion (s)	Duration of convulsion (s)	Mortality (% death)	% protection
Control	89.20 ± 4.24	56.77 ± 0.19	6/6 (100)	0.0
Diazepam (5 mg/kg, i.p.)	527.11 ± 6.11**	26.65 ± 0.93**	0/6 (0.0)	100
SCMeOH 125	301.82 ± 5.43	41.30 ± 0.20	2/6 (33.33)	66.6
SCMeOH 250	441.67 ± 2.10*	34.62 ± 1.55*	1/6 (16.66)	83.32
SCMeOH 500	511.12 ± 2.11**	20.99 ± 2.24**	0/6 (0.00)	100

Control (vehicle)—distilled water.
The data represent the mean ± SD (𝑛=6). *𝑃<0.01, **𝑃<0.001 significantly different compared to NIH induced seizure control.