Evaluation of Anticonvulsant, Sedative, Anxiolytic, and Phytochemical Profile of the Methanol Extract from the Aerial Parts of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke

Table 3

Effect of methanol extract of Swertia corymbosa (SCMeOH) on tonic seizures induced by maximal electroshock in rats.

Treatment (mg/kg)	Seizure onset time (s)	Duration of tonic hind limb extension (s)
Control	8.38 ± 1.88	12.88 ± 0.35
Diazepam (5 mg/kg, i.p.)	19.88 ± 1.35	2.63 ± 1.72**
SCMeOH 125	28.81 ± 1.10	8.28 ± 1.19
SCMeOH 250	32.43 ± 1.44*	7.44 ± 1.01*
SCMeOH 500	48.84 ± 1.25**	3.21 ± 1.25**

Control (vehicle)—distilled water.
The data represent the mean ± SD (𝑛=6). *𝑃<0.05, **𝑃<0.01 significantly different compared to maximal electroshock induced seizure control.