Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis

Figure 1

The role of TLR4 in epithelium injury and repair mechanisms. Many factors typical of prenatal birth such as infections, inappropriate enteral nutrition, antibiotics use, microcirculatory dysfunction, and hypoxia induce epithelial injury. Hyperactivation of TLR4 signaling affects the healing process favoring pathological bacteria translocation across epithelial barrier.