Research Article
Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment
Table 3
Formulation of floating pulsatile tablet.
| |
Batch code | Coded levels |
Polyox WSR205
(mg) |
Xanthan gum
(mg) |
Citric acid
(mg) |
Sodium bicarbonate
(mg) |
Dicalcium phosphate
(mg) |
Core tablet
(mg) | Variable 1
(Polyox WSR205) | Variable 2
(Xanthan gum) |
| | F1 | −1 | −1 | 157.5 | 45 | 0.46 | 4.6 | 47.44 | 70 | | F2 | 1 | 0 | 180 | 67.5 | 0.46 | 4.6 | 2.44 | 70 | | F3 | 0 | 0 | 167.5 | 57.5 | 0.46 | 4.6 | 24.94 | 70 | | F4 | −1 | 0 | 157.5 | 57.5 | 0.46 | 4.6 | 34.94 | 70 | | F5 | −1 | 1 | 157.5 | 67.5 | 0.46 | 4.6 | 24.94 | 70 | | F6 | 0 | −1 | 167.5 | 45 | 0.46 | 4.6 | 37.44 | 70 | | F7 | 0 | 1 | 167.5 | 67.5 | 0.46 | 4.6 | 14.94 | 70 | | F8 | 1 | −1 | 180 | 45 | 0.46 | 4.6 | 24.94 | 70 | | F9 | 1 | 1 | 180 | 57.5 | 0.46 | 4.6 | 12.44 | 70 |
|
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Total weight of Tablet = 325 mg.
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