Research Article
Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment
Table 4
Evaluation of FPRTs.
| | Batch code | Hardness
(Kg/cm2)
| Buoyancy time
(sec)
| Drug release after lag time
(%)
| Lag time
(h)
|
| | F1 | 5.5 ± 0.1 | 45 ± 3 | 93.77 ± 2 | 4 ± 0.5 | | F2 | 6.5 ± 0.2 | 900 ± 6 | 71.56 ± 3 | 8 ± 0.1 | | F3 | 6 ± 0.1 | 33 ± 5 | 69.21 ± 5 | 7 ± 0.1 | | F4 | 6 ± 0.2 | 40 ± 4 | 94.71 ± 2 | 4 ± 0.3 | | F5 | 7 ± 0.2 | 900 ± 8 | 92 ± 3 | 4 ± 0.4 | | F6 | 6 ± 0.1 | 35 ± 2 | 84.1 ± 4 | 4 ± 0.3 | | F7 | 6.5 ± 0.1 | 60 ± 4 | 97.87 ± 1 | 2 ± 0.5 | | F8 | 6 ± 0.1 | 55 ± 2 | 98.69 ± 2 | 7 ± 0.1 | | F9 | 6 ± 0.1 | 50 ± 3 | 83.15 ± 3 | 6 ± 0.1 |
|
|
; values are expressed in mean ± SD (standard deviation).
|
