Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment

Table 5

Statistical analysis of kinetics data of drug release.

Batch code	Zero order	1st order	Matrix	Korsmeyer-Peppas			Hixson Crowell	Best fit model
	F1	0.9994	0.9996	0.9724	0.9756	0.6881	30.0459		0.9998	Hixson Crowell
F2	0.7084	0.6532	0.5837	0.8490	1.0365	2.3164	0.6711	Korsmeyer-Peppas
F3	0.8265	0.7953	0.6804	0.8829	1.4226	2.0525	0.8054	Korsmeyer-Peppas
F4	0.7003	0.6777	0.5547	0.8764	2.5080	0.8631	0.6845	Korsmeyer-Peppas
F5	0.7920	0.7478	0.6423	0.9495	2.4981	1.2806	0.7621	Korsmeyer-Peppas
F6	0.6859	0.6679	0.5421	0.7683	2.1137	1.2038	0.6732	Korsmeyer-Peppas
F7	0.8535	0.8460	0.7275	1.000	4.9821	2.3469	0.8483	Korsmeyer-Peppas
F8	0.5790	0.5419	0.4472	0.7728	1.4752	0.9012	0.5527	Korsmeyer-Peppas
F9	0.6776	0.6316	0.5335	0.8806	1.7938	0.9048	0.6460	Korsmeyer-Peppas