Biomarkers for Sepsis

Table 2

Evaluation of new biomarkers of sepsis.

New Biomarkers	Level	Sensit.	Specif.	AUC	NPV	PPV	Prevalence; (%)	Type	Study
sTREM-1; (pg/mL)	40–755*	79	80	0.87	70	86	1113/1795 (62)	Diagnostic	[34]
Pro-ADM (nmol/L)	4.86	53	84	0.72	77	64	47/137 (34.7)	Prognostic	[44]
suPAR (ng/mL)	10	80	77	0.79	95	42	27/125 (21.6)	Diagnostic	[39]
	8.9	66	64	0.73	76	50	94/258 (36.43)	Diagnostic	[40]
Presepsin (pg/mL)	2866	79	62	0.70	87	45	55/189 (29)	Diagnostic	[47]
	1606	72	70	0.74	71	71	71/100 (71)	Prognostic	[48]
	317	71	86	0.82	52	93	372/859 (43.3)	Diagnostic	[49]
	556	62	67	nr	78	48	283/859 (32.94)	Prognostic	[49]

Sensit.: sensitivity, specif: specificity, AUC: area under curve, NPV: negative predictive value, PPV: positive predictive value, and nr: not reported.
*Cutoff point based in a meta-analysis of 11 studies.