Molecular and Cellular Basis of Autosomal Recessive Primary Microcephaly

Figure 1

Centrosome structure. Centrosomes are small organelles composed of two perpendicular centrioles (orange cylinders), a mother and a daughter, linked together by interconnecting fibres (dark green). The centrioles are surrounded by an amorphous pericentriolar matrix (dotted orange background) involved in the nucleation and anchoring of cytoplasmic microtubules. Contrary to the daughter centriole, the mother centriole possesses distal (purple) and subdistal (blue) appendages necessary for cilia assembly and microtubule anchoring, respectively.