Molecular and Cellular Basis of Autosomal Recessive Primary Microcephaly

Figure 2

Microcephaly protein interaction network. The majority of microcephaly proteins (red) are associated with centrosomes. CENPJ, STIL, and CEP135 are components of centrioles (green box), while MICROCEPHALIN, CDK5RAP2, and CEP152 are part of the PCM (orange background). WDR62, ASPM, and CDK6 temporarily localize to the PCM. In addition, CASC5 and PHC1 are known to interact with proteins at the centrosome. For ZNF335, its precise connection to the centrosome is not understood. Microcephaly proteins are physically linked to one another either directly or indirectly (solid black lines) to form a protein network.