EBV, HCMV, HHV6, and HHV7 Screening in Bone Marrow Samples from Children with Acute Lymphoblastic Leukemia

Table 1

Demographic and clinic characteristics of the patients .

Age at diagnosis (years)	Median (range)
	7.6 (0.8–15.7)
Gender	(%)
Male	33 (47)
Female	37 (53)
Birthplace	(%)
Mexico City	63 (91)
Other Southern Mexican States	7 (9)
Percentage of blasts in bone marrow	Average (range)
	87% (25%–100%)
Immunophenotype*	(%)
B-cell precursor	66 (94.3)
T-cell	4 (5.7)
FAB classification	(%)
L1	43 (62)
L2	26 (36)
L3	1 (2)
Genetic rearrangements**	(%)
ETV6-RUNX1	6 (12)
E2A-PBX1	2 (4)
No rearrangement	42 (84)

Immunophenotype was determined according to international parameters [54].
**Molecular diagnosis of ETV6-RUNX1, E2A-PBX1, MLL-AF4 and major and minor BCR-ABL genetic rearrangements were performed only in 50 samples. Percentages shown were calculated using 50 as denominator.