Detection of Single Umbilical Artery in the First Trimester Ultrasound: Its Value as a Marker of Fetal Malformation

Table 1

Clinical cases with SUA accompanying other major ultrasound abnormalities.

Number	Diagnostic weeks SUA	Findings in the 12th week ultrasound	Subsequent findings (from the 14th week to the finish of pregnancy)	Karyotype	Outcome
1	𝟏𝟐+𝟐	Tricuspid regurgitation, agenesis of the ductus venosus, and intestinal dilatation	16th week: interventricular communication	Normal	Preterm newborn (33rd week) with tracheal agenesis, intestinal pathology, and heart disease. He died after birth. Autopsy: VACTERL association.
2	𝟏𝟐+𝟐	Agenesis of the ductus venosus	20th week: interventricular communication, choroid plexos cysts	Normal	Preterm newborn (31st week) with congenital heart disease, imperforate anus, and external auditory canal atresia.
3	𝟏𝟏+𝟒	Increased nuchal translucency. Situs ambiguous, atrioventricular (AV) canal defects. Right atrial isomerism			Miscarriage (15th week)
4	𝟏𝟐+𝟒	Hypoplastic right ventricle. Tricuspid atresia/dysplasia			Loss to follow
5	𝟏𝟐+𝟐	Hygroma with chromosomal markers	16th week: Overriding aorta	Normal	Abortion (TOP)
6	𝟏𝟐+𝟏	Encephalocele, hydrocephalus, intestinal and liver herniation		Normal	Termination of pregnancy
7	𝟏𝟐+𝟎	Facial malformation	14th week: bilateral cleft lip, persistent right superior vena cava	Normal	Miscarriage (15th week)
8	𝟏𝟏+𝟓	Bladder augmentation, hydronephrosis, ARSA, ductus venosus position anomalies, increased nuchal translucency, polydactyly		T13	Miscarriage (13th week)
9	𝟏𝟐+𝟐	Truncus arteriosus, interventricular communication		T18	Termination of pregnancy
10	𝟏𝟐+𝟑	Hypoplastic left ventricle, cystic hygroma, and agenesis of the ductus venosus.		Normal	Termination of pregnancy
11	𝟏𝟏+𝟔	Fetal hydrops, omphalocele		45X0	Termination of pregnancy
12	𝟏𝟐+𝟑	Ectopia cordis, omphalocele, and amniotic bands		Normal	Termination of pregnancy
13	𝟏𝟑+𝟎	Caudal agenesis		Normal	Miscarriage (14th week)
14	𝟏𝟏+𝟎	Bilateral aplasia of forearm bones			Termination of pregnancy
15	𝟏𝟏+𝟔	Tricuspid regurgitation, pericardial effusion, and umbilical hernia		T18	Termination of pregnancy
16	𝟏𝟏+𝟑	Cystic hygroma, hypoplastic upper limb, and trident hand		Normal	Termination of pregnancy
17	𝟏𝟑+𝟏		17th week: cleft lip, pathology of the aorta	Normal	Termination of pregnancy
18	𝟏𝟐+𝟔		16th week: interventricular communication, ARSA; 20th week: partial agenesis of the corpus callosum	T18	Stillbirth (31st week)
19	𝟏𝟑+𝟏		18th week: choroid plexos cysts.; 25th week: hyperechoic vermis and tortuous umbilical vein	Normal	Normal newborn
20	𝟏𝟐+𝟒		17th week: hydrocephalus, bilateral agenesis of forearm bones	Normal	Termination of pregnancy
21	𝟏𝟐+𝟐		14th week: malformations of the upper limbs and hyperdense bowel		Termination of pregnancy
22	𝟏𝟐+𝟔		16th week: bilateral renal cysts	Normal	Termination of pregnancy