The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target

Figure 3

AAA+inhibitors. (a) The basic quinolone structure and substitution numbering scheme are shown. From a previous study [63], most of the better Mcm2-7 inhibitors required both the nitrogen at position one and a nitrogen-containing substituent at position 7, with variation to the position 7 substituent often appearing to strongly module inhibitor activity. (b) Examination of inhibition of Mcm2-7 and SV-40 large T antigen comparing related fluoroquinolone and triazole inhibitors [63]. (c) SV-40 large T antigen inhibitors shown [64]. (d) Basic quinazoline structure shown; R-group substituents are discussed in the text.