The Effect of Multiple Single Nucleotide Polymorphisms in the Folic Acid Pathway Genes on Homocysteine Metabolism

Table 3

Association between SNPs and Hcy.

SNP	Wide type		Heterozygous		Homozygous		𝑃
	𝑁	Hcy level	𝑁	Hcy level	𝑁	Hcy level
MTHFR (rs1801131)	266	4.836±0.064	108	4.665±0.101	11	4.824±0.316	0.154
MTHFR (rs1801133)	132	4.594±0.089	171	4.736±0.078	83	5.23±0.113	<0.001
MTHFR (rs3737965)	331	4.838±0.058	53	4.449±0.144	2	5.098±0.739	0.029
MTR (rs1805087)	312	4.804±0.06	68	4.751±0.128	3	4.31±0.609	0.42
MTRR (rs162036)	245	4.793±0.054	125	4.785±0.121	13	4.913±0.376	0.562
MTRR (rs1801394)	214	4.817±0.072	150	4.74±0.086	21	4.824±0.229	0.49
MTRR (rs2287780)	257	4.813±0.066	117	4.751±0.098	8	4.596±0.372	0.565
MTRR (rs2303080)	317	4.788±0.059	61	4.819±0.135	4	4.742±0.525	0.838
BHMT (rs3733890)	183	4.835±0.078	166	4.707±0.082	31	4.973±0.189	0.262
MTHFD1 (rs2236225)	212	4.837±0.072	147	4.767±0.087	26	4.574±0.206	0.229
SHMT1 (rs1979277)	341	4.875±0.057	43	4.855±0.161	0	—	0.68
RFC1 (rs1051266)	73	4.895±0.123	210	4.753±0.072	100	4.766±0.105	0.227
CBS (rs234713)	364	4.81±0.055	22	4.503±0.224	0	—	0.183
CBS (rs2851391)	200	4.75±0.074	149	4.755±0.86	37	5.075±0.172	0.083
TCN2 (rs9606756)	373	4.793±0.054	13	4.785±0.291	0	—	0.979

Values are presented as mean ± standard deviation.
𝑃: the 𝑃 value of analysis of variance between 3 different genotypes of SNPs and homocysteine concentration. The covariate folic acid concentrations were from 14.584 to 15.362 ng/mL. Hcy: homocysteine; SNP: single nucleotide polymorphisms.