The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

Figure 1

Schematic representation of the remodeling theory. The genetics-environment interactions as a function of age are represented as the fitness between the screwdrivers (genotype) and screw head shape (cross or cut). In particular, the different gene-environment interaction is represented by different ratio between the screw head shape. According to the remodeling theory, the interaction between the same genotype and time-related physiological conditions could result in different fitness, as shown in the three plots (fitness versus age). In particular, the highest fitness values for each genotype are coloured (red, blue, and green).