Molecular Chaperones, Cochaperones, and Ubiquitination/Deubiquitination System: Involvement in the Production of High Quality Spermatozoa

Table 1

Family	Name	Expression/localization and/or function	Species	References
DNAJ/HSP40	DnaJA1/DnaJA2	Spermiogenesis/androgen signaling	Mus musculus	[90]
	DnaJB1	Spermatocytes, round and elongating spermatids, sperm tail, and acrosome	Mus musculus; Rattus norvegicus	[91]
	Msj-1 (DnaJB3)	Postmeiotic cells and spermatozoa, follows the contour of developing acrosome	Mus musculus	[63, 66]
	Mfsj-1	Spermatids	Macaca fuscata	[92]
	rDJL	Acrosome region of spermatozoa, participates in vesicular trafficking	Rattus norvegicus	[93]
	Tsarg-1/-3*/-6	Inhibits spermatogenetic cell apoptosis	Mus musculus; Rattus norvegicus; Homo sapiens	[94]; [95]; [96, 97]
	DnaJB13	Axoneme formation	Mus musculus	[98]
USPs/UBPs	Usp2	Sperm motility and fertilization	Mus musculus	[99]
	Ubpy/Usp8	Acrosome biogenesis	Mus musculus	[67, 85, 87]
	Usp9Y	Male germ cell development	Homo sapiens	[100, 101]
	Usp14	Spermatid differentiation	Mus musculus	[102]
	Usp25	Testis	Mus musculus	[103]
	Usp26	Suggested role in sperm motility; Blood-testis barrier and sperm head; regulator of germ-cell movement along the seminiferous epithelium	Homo sapiens; Mus musculus	[104]; [105]
	Usp42	Pachytene spermatocytes, round spermatids, and condensing spermatids	Mus musculus	[106]
	Usp44	Leydig cells and seminiferous epithelium	Mus musculus	[107]
UCHs	Uch-L1	Spermatogonia, Sertoli cells, caput epididymis, and vas deferens; Mitotic proliferation, proapoptotic role during the progression of spermatogenesis and the transit in the epididymis	Mus musculus	[48, 108–110]
	Uch-L3	Meiotic pachytene spermatocytes and postmeiotic spermatids; cauda epididymis; Sperm quality control during epididymal maturation	Mus musculus	[48, 109, 110]
	Uch-L4	All tissues, with testis included	Mus musculus	[111]
	Uch-L5	Spermatocytes and spermatids	Mus musculus	[112]
	CYLD	Control of spermatogenetic cell apoptosis and spermatogenesis progression via RIP1/NF-kappaB signalling axis	Mus musculus	[113]

∗Indicates “also known as DnaJB13”.