Acute Toxicity Study of Zerumbone-Loaded Nanostructured Lipid Carrier on BALB/c Mice Model
Table 1
Body weight of mice treated with ZER, nanostructured lipid carrier (NLC), and zerumbone-loaded NLC.
Animal groups
Female
Male
Body weight (g)
Body weight (g)
Day 0
Day 7
Day 14
Weight gain (g) on day 14
Day 0
Day 7
Day 14
Weight gain (g) on day 14
Control
19.3 ± 1.05
23.6 ± 1.0
28.2 ± 0.8*
8.9 ± 0.26
21.0 ± 0.8
25.6 ± 1.0
30.3 ± 0.8*
9.3 ± 0.65
Vehicle
20.1 ± 1.7
23.14 ± 1.5
29.11 ± 0.77*
9.01 ± 0.95
21.49 ± 1.4
25.7 ± 1.9
30.20 ± 0.95*
8.71 ± 1.45
ZER (100 mg/kg)
20.5 ± 0.5
24.15 ± 0.9
28.75 ± 1.1*
8.25 ± 0.63
20.9 ± 1.3
24.85 ± 1.5
29.7 ± 1.6*
8.8 ± 1.25
ZER (200 mg/kg)
20.8 ± 0.7
24.65 ± 1.4
28.9 ± 3.2*
8.1 ± 1.75
21.3 ± 1.5
24.4 ± 0.9
28.9 ± 1.45*
7.6 ± 1.8
NLC (100 mg/kg)
19.6 ± 1.3
23.3 ± 2.1
27.6 ± 2.2*
7.9 ± 1.7
21.7 ± 0.2
26.3 ± 0.6
31.2 ± 1.1*
9.4 ± 1.0
NLC (200 mg/kg)
20.0 ± 1.7
24.5 ± 2.2
29.9 ± 2.0*
9.9 ± 0.3
19.7 ± 1.6
25.1 ± 0.9
30.4 ± 1.0*
10.6 ± 0.7
ZER-NLC (100 mg/kg)
19.6 ± 0.2
23.2 ± 1.1
26.0 ± 1.1*
6.4 ± 0.8
21.0 ± 0.9
24.2 ± 1.0
28.2 ± 0.8*
8.2 ± 1.4
ZER-NLC (200 mg/kg)
19.5 ± 0.8
23.3 ± 0.5
26.8 ± 0.9*
7.3 ± 1.5
19.1 ± 1.0
24.4 ± 0.9
26.6 ± 0.7*
7.5 ± 0.7
Values are mean ± SD () and have been analysed using post hoc comparison test one way ANOVA. Data revealed significant . *Increasing of body weight after 14 days in all treated groups when compared to that of untreated control group.
