Improvements in Memory after Medial Septum Stimulation Are Associated with Changes in Hippocampal Cholinergic Activity and Neurogenesis
Figure 1
Effect of MS-DBS on spatial memory. Latency indicates the time required for the rat to find the escape platform during training trails. During training trails, all groups gradually acquired the location of the platform (a). After a delay of two days, spatial memory was improved by MS-DBS (b). Time spent in the platform zone () and number of crossings () was significantly different between lesion and normal groups. However, the stimulation group did not differ from the normal group. There was no disruption of motor function in any group. Data are shown as mean SEM (a). Indices are expressed as the percentage of normal group values (b). MS: medial septum; DBS: deep brain stimulation: Dist: distance.
