Research Article

The Significance of Serum Phosphate Level on Healing Index and Its Relative Effects in Skeletally Immature and Mature Patients with Hypophosphatemic Rickets

Table 5

Meta-analysis of deformity correction reports on hypophosphatemic rickets patients.

Author (year)#Age (range)Segment and method of operationFixation methodSerum phosphate level (range)Healing indexComplications

Rubinovitch et al. (1988) [14]108 years
(5–13)
26 tibiae, 16 femurs, 2 subtrochanteric shortening and compression plating34 compression plates, 2 Sherman plates, and 2 staplesNRNR27% recurrence, anterior tibial compartment syndrome

Choi et al. (2002) [2]1413.9 years
(3.2–22)
8 femurs, 4 tibiae in DC; 9 femurs, 19 tibiae in DCLIlizarov EF2.3 mg/dL
(1.3–3.0)
2.2 months/cm
—DO
1 premature consolidation, 1 refracture, and 2 peroneal nerve palsies

Song et al. (2006) [10]2020 years
(8–41)
20 femurs, 35 tibiae; 28 DCL, 27 acute DC24 EF, 6 IM, 25 IM + EF2.0 mg/dL
(1.4–2.8)
2.6 months/cm—DO with EF
2.7 months/cm—DO with EF and IM
Recurrent deformity, equinus contracture, knee stiffness, and pin tract infection

Matsubara et al. (2008) [3]333.2 years
(24–46)
6 femurs, 4 tibiae; DCL9 Ilizarov EF, 1 Heidelberg EF2.1 mg/dL
(2.10–2.3)
NRNone

Petje et al. (2008) [4]108.3 years
(4–11)
30 femurs, 35 tibiae; DC53 EF, 19 Ilizarov, 18 Kirschner wires2.1 mg/dL
(2.0–2.7)
NRFemoral fracture, pin tract infection, and 90% recurrence rate

Current study12 M23 years
(18.3–31.2)
12 tibiae; 8 DC(L), 4 DCLIlizarov EF2.2 mg/dL
(1.7–2.8)
1.68 months/cmShown in Table 4
27 IM9.6 years
(3.8–15.8)
27 tibiae; 12 DC(L), 15 DCL2.6 mg/dL
(1.9–3.5)
1.44 months/cm

#: number of patients; M: group mature; IM: group immature; DO: distraction osteogenesis; DC: deformity correction; DC(L): acute correction and concomitant lengthening; DCL: gradual correction and lengthening; EF: external fixation; IM: intramedullary nailing; NR: not reported.