Aberrant Frequency of IL-10-Producing B Cells and Its Association with Treg/Th17 in Adult Primary Immune Thrombocytopenia Patients

Figure 2

Decreased number of Tregs in patients with ITP. (a) Representative dot plots of Tregs (CD25⁺Foxp3⁺, gated on CD4⁺ cells) in one healthy subject and one ITP patient before and after first-line therapies. (b) Decreased frequency of Tregs can be improved by first-line therapies in ITP patients. (c) The expression of FOXP3 mRNA was also decreased in ITP patients. (d) The deficiency in the number of Tregs was corrected by first-line therapies in R patients, but not in NR patients. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001.

(a)

(b)

(c)

(d)