The Influence of Ionizing Radiation, Temperature, and Light on Eplerenone in the Solid State

Table 4

Eplerenone and impurities of unknown structure in degraded and nondegraded samples.

Conditions	Recovery* [%]
	a; 3.57 min	b; 3.79 min	c; 4.40 min	d; 4.64 min	e; 5.15 min	f; 5.49 min	g; 5.87 min	h; 6.48 min	i; 8.03 min	j; 8.83 min	k; 9.17 min	l; 16.64 min	m; 17.89 min	n; 19.71 min
Nondegraded	0.015	0.012				0.030	0.024	0.036	0.031		0.01		0.018
6 mln lux h	0.013	0.014			0.112	0.033	0.027	0.035	0.021	0.038	0.009		0.021
90°C RH 0%	0.010	0.014			0.009	0.034	0.028	0.035	0.139	0.017	0.011		0.023
60°C RH 76.4%	0.012	0.013			0.009	0.070	0.025	0.035	0.017				0.025
25 kGy	0.022	0.011					0.038	0.011	0.012			0.019	0.035	0.021
50 kGy		0.022	0.010				0.063	0.055	0.037			0.030	0.104	0.019
100 kGy		0.026	0.018	0.021			0.093	0.106	0.024			0.021	0.183
200 kGy		0.034	0.033	0.037	0.022	0.017	0.146	0.187	0.056			0.025	0.338
400 kGy		0.049	0.063	0.064	0.033	0.021	0.249	0.365	0.065			0.026	0.557

∗Content of unknown impurities calculated for their relative response factor equal to that of eplerenone.