The Influence of Ionizing Radiation, Temperature, and Light on Eplerenone in the Solid State

Table 5

Results of DSC analysis. The values in parentheses are standard deviation.

Conditions	Temperature [°C]			Difference [°C]
	𝑇onset	𝑇max	𝑇endset	𝑇onset𝐸−𝑇onset	𝑇max𝐸−𝑇max	𝑇endset𝐸−𝑇endset
Nondegraded	234.5 (3)	248.5 (0)	253.5 (3)	—	—	—
6 mln lux h	232.6 (0)	248.3 (3)	253.2 (0)	−1.9	−0.2	0.0
90°C RH 0%	232.3 (6)	248.5 (0)	253.7 (3)	−2.2	0.0	−0.3
60°C RH 76.4%	231.7 (3)	248.2 (7)	253.6 (7)	−2.8	−0.2	+0.2
25 kGy	227.6 (7)	246.1 (3)	249.8 (3)	−6.8	−2.4	−3.7
50 kGy	227.3 (3)	245.7 (0)	249.3 (7)	−7.2	−2.8	−4.1
100 kGy	226.4 (3)	244.1 (3)	247.8 (3)	−8.1	−4.4	−5.7
200 kGy	226.7 (3)	242.0 (7)	246.5 (0)	−7.8	−6.4	−7.0
400 kGy	227.5 (0)	239.6 (3)	242.5 (7)	−7.0	−8.9	−10.9

𝑇_onset𝐸: melting peak onset for nondegraded eplerenone.
𝑇_max𝐸: melting peak maximum for nondegraded eplerenone.
𝑇_endset𝐸: melting peak endset temperature for nondegraded eplerenone.