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BioMed Research International
Volume 2014, Article ID 572409, 10 pages
Research Article

Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level

1Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 30050, Taiwan
2Center for Bioinformatics Research, National Chiao Tung University, Hsinchu 30050, Taiwan
3Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, Martín de Irigoyen 3100, San Martín, 1650 Buenos Aires, Argentina

Received 28 February 2014; Revised 6 June 2014; Accepted 9 June 2014; Published 9 July 2014

Academic Editor: Liam McGuffin

Copyright © 2014 So-Wei Yeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material contains a list of the 216 monomeric enzymes used in the manuscript shown in Table S1. All details of the statistical tests used in this study are shown in Table S2 to S7. The results based on Spearman correlations are shown in Figure S1, S2, and S3, and Table S8 to S15.

  1. Supplementary Materials