Conversion to Sirolimus Ameliorates Cyclosporine-Induced Nephropathy in the Rat: Focus on Serum, Urine, Gene, and Protein Renal Expression Biomarkers

Figure 1

Semiquantitative evaluation of vascular (a), glomerular (b), and tubulointerstitial (c) lesions. Each graphic represents one lesion for the 3 groups at week 3 (control, cyclosporin A, and sirolimus) and 4 groups at week 9 (control, cyclosporin A, sirolimus, and conversion). Values are mean ± SEM. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 versus control; ^#𝑃<0.05 and ^###𝑃<0.001 versus cyclosporin; ^§𝑃<0.05 and ^§§𝑃<0.01 versus sirolimus. GBM thickening, glomerular basement membrane thickening.

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(b)

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