Impact of Core-Forming Segment Structure on Drug Loading in Biodegradable Polymeric Micelles Using PEG-b-Poly(lactide-co-depsipeptide) Block Copolymers
Table 2
Results of preparation of fluorescein-loaded polymeric micelles.
Code
Fluorescein in feed [wt%]
Yield mg (%)
PR [%]
DL [%]
EE [%]
DR [%]
b-PLLA(0)
0
21.0 (84)
84
0.0
—
—
b-PLLA(10)
10
16.7 (60)
60
10.4
104
63
b-PLLA(15)
15
16.0 (54)
55
13.5
90
49
b-PLLA(20)
20
14.4 (46)
48
16.9
85
39
b-PLLA(25)
25
12.1 (36)
40
17.9
72
26
b-PLLA(30)
30
7.0 (20)
23
16.6
60
11
b-PLLA(35)
35
1.6 (4)
5
14.5
41
1.7
b-PDLLA(0)
0
22.3 (89)
89
0.0
—
—
b-PDLLA(10)
10
22.3 (80)
79
11.6
116
93
b-PDLLA(15)
15
20.0 (68)
69
13.9
92
63
b-PDLLA(20)
20
21.2 (68)
71
16.3
82
55
b-PDLLA(25)
25
16.9 (51)
56
17.8
71
36
b-PDLLA(30)
30
13.8 (39)
44
20.0
67
26
b-PDLLA(35)
35
2.7 (7)
9
19.9
57
4.0
b-PLGL20(0)
0
22.0 (89)
89
0.0
—
—
b-PLGL(25)
25
24.9 (75)
78
21.7
87
65
b-PLGL(30)
30
23.1 (65)
72
21.7
72
47
b-PLGL(35)
35
12.9 (34)
41
20.2
58
19
b-PLGL(40)
40
5.2 (12)
16
22.0
55
6.9
b-PLGL(0)
0
20.4 (82)
82
0.0
—
—
b-PLGL(25)
25
26.8 (80)
83
22.4
90
72
b-PLGL(30)
30
29.7 (83)
86
27.8
93
77
b-PLGL(35)
35
18.9 (49)
56
25.3
72
36
b-PLGL(40)
40
6.6 (16)
20
25.6
64
10
b-PLGL(0)
0
20.7 (83)
83
0.0
—
—
b-PLGL(25)
25
27.6 (83)
82
25.5
102
85
b-PLGL(30)
30
25.8 (72)
73
29.0
97
70
b-PLGL(35)
35
19.5 (51)
55
29.2
83
42
b-PLGL(40)
40
9.0 (22)
27
24.1
60
13
b-PLGL(0)
0
22.6 (90)
90
0.0
—
—
b-PLGL(25)
25
26.5 (80)
81
24.0
96
76
b-PLGL(30)
30
28.1 (79)
81
27.7
92
73
b-PLGL(35)
35
19.8 (51)
56
29.0
83
43
b-PLGL(40)
40
7.1 (17)
20
29.6
74
12.6
b-PLGL(0)
0
22.8 (91)
91
0.0
—
—
b-PLGL(25)
25
26.9 (81)
81
24.8
99
80
b-PLGL(30)
30
25.7 (72)
72
29.6
99
71
b-PLGL(35)
35
19.2 (50)
55
28.9
83
41
b-PLGL(40)
40
11.1 (27)
32
28.5
71
19
b-PLGF(0)
0
23.0 (92)
92
0.0
—
—
b-PLGF(24)
25
22.9 (69)
73
20.6
82
57
b-PLGF(30)
30
22.3 (62)
68
23.7
79
49
b-PLGF(35)
35
12.7 (33)
39
24.1
68
23
b-PLGF(40)
40
8.8 (21)
27
22.0
55
12
b-PLGF(0)
0
20.8 (83)
83
0.0
—
—
b-PLGF(25)
25
26.4 (79)
82
22.8
91
72
b-PLGF(30)
30
22.8 (64)
69
24.6
82
52
b-PLGF(35)
35
11.0 (29)
32
26.2
75
21
b-PLGF(40)
40
4.6 (11)
14
22.4
56
6.2
b-PLGF(0)
0
22.3 (89)
89
0.0
—
—
b-PLGF(25)
25
23.4 (70)
71
23.6
95
66
b-PLGF(30)
30
18.6 (52)
56
24.1
80
42
b-PLGF(35)
35
13.4(35)
40
25.4
72
25
b-PLGF(40)
40
6.4 (15)
18
28.4
71
11
PR (%) = (polymer found)/( polymer in feed) (w/w) 100. DL (%) = (drug found)/(micelle found) (w/w) 100. EE (%) = [(drug found)/(micelle found)]/[(drug in feed)/(micelle in feed)] (w/w) 100. DR (%) = (drug found)/(drug in feed) (w/w) 100.
