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BioMed Research International
Volume 2014, Article ID 580373, 5 pages
Research Article

Cystic Fibrosis and New Trends by Ophthalmological Evaluation: A Pilot Study

1Department of Sense Organs, Ocular Electrophysiology Center, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy
2Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy
3Department of Pediatrics and Pediatric Neurology, Cystic Fibrosis Center, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy
4Department of Ophthalmology, Polo Pontino, A. Fiorini Hospital, Via Firenze, 04019 Terracina, Italy

Received 28 February 2014; Revised 3 June 2014; Accepted 11 June 2014; Published 15 July 2014

Academic Editor: Flavia Prodam

Copyright © 2014 Marcella Nebbioso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Cystic fibrosis (CF) is characterized by hypoxia that affects several organic tissues. Retinal ganglion cells may suffer from the hypoxic status, and this may lead to alterations of retinal nerve fiber. Methods. Twenty-two eyes in CF patients were analyzed. A complete ocular evaluation and visual field exams of the 30 central degrees were performed using the frequency doubling technology (FDT). Forced expiratory volume in one second (FEV1%), forced vital capacity (FVC%), oxyhaemoglobin saturation (SpO2%), and hematocrit (Ht%) have been calculated. FDT analyzed parameters were mean deviation (MD) and pattern standard deviation (PSD). Pearson’s correlation was chosen as statistical analysis. Results. Data showed statistically significant relationship between MD and Ht% ( value −0.18; ), MD and FEV1% ( value −0.68; ), and MD and FVC% ( value −0.45; ). Moreover, there were correlations between PSD and Ht% ( value 0.29; ), PSD and SpO2% ( value −0.31; ), PSD and FEV1% ( value 0.71; ), and PSD and FVC% ( value 0.63; ). Conclusions. The oxygen supply alterations might determine hypoxia of the ganglion cells causing a decrease of receptive optic nerve fiber activity. This method could be also useful to evaluate indirectly pulmonary activity of the CF disease.