Oral and Intraperitoneal Administration of Quercetin Decreased Lymphocyte DNA Damage and Plasma Lipid Peroxidation Induced by TSA In Vivo
Figure 2
Total (a and b) and individual (c) concentrations of quercetin (Q) and its metabolites in plasma of tumor-bearing mice with various treatments as well as the HPLC chromatograms in the plasma (d). Thirty-six male nude mice were injected with A549 cells and after 3 weeks were treated with TSA alone (0.5 mg/kg body weight) or in combination with Q (OL and OH, Q administered orally at 20 and 100 mg/kg body weight, respectively; IL and IH, Q administered intraperitoneally at 2 and 10 mg/kg body weight, resp.) for 16 weeks as described in Section 2. The control group was administered the vehicle only. After various treatments for 4–10 weeks, total Q concentrations were determined after Q administration. Individual concentration of Q, quercetin-3-glucuronide (Q3G), and quercetin-3′-sulfate (Q3′S) in the plasma in OH+TSA and IH+TSA groups were determined at 1 h and 10 minutes after Q administration, respectively. Values are expressed as means ± SD () and those of the same compound not sharing a common letter are significantly different ().
