PTEN Mediates the Antioxidant Effect of Resveratrol at Nutritionally Relevant Concentrations
Figure 3
Resveratrol inactivates the Akt signaling pathway through PTEN activation in MCF-7 cells. Phospho-Akt levels were measured by Western blotting, after 48 h incubation with resveratrol (1 nM) alone, potassium bisperoxo (bipyridine) oxovanadate (V) as a PTEN inhibitor alone (20 nM), or both together. Histograms represent densitometric measurement of specific bands of phospho-Akt content using tubulin levels as housekeeping control. Data are expressed as means + SD for 4 independent experiments; versus control.
