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BioMed Research International
Volume 2014, Article ID 583035, 9 pages
Research Article

Intra-QT Spectral Coherence as a Possible Noninvasive Marker of Sustained Ventricular Tachycardia

1Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, “Sapienza” University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy
2Division of Cardiology, S. Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Piazza Ponte dei Quattro Capi, 39 186 Roma, Italy
3Dipartimento di Medicina Clinica e Molecolare, S. Andrea Hospital, “Sapienza” University of Rome, Via di Grottarossa 1035/1039, 00189 Roma, Italy

Received 18 March 2014; Accepted 28 May 2014; Published 15 July 2014

Academic Editor: Jason Ng

Copyright © 2014 Gianfranco Piccirillo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sudden cardiac death is the main cause of mortality in patients affected by chronic heart failure (CHF) and with history of myocardial infarction. No study yet investigated the intra-QT phase spectral coherence as a possible tool in stratifying the arrhythmic susceptibility in patients at risk of sudden cardiac death (SCD). We, therefore, assessed possible difference in spectral coherence between the ECG segment extending from the wave to the T wave peak () and the one from T wave peak to the T wave end (Te) between patients with and without Holter ECG-documented sustained ventricular tachycardia (VT). None of the QT variability indexes as well as most of the coherences and RR power spectral variables significantly differed between the two groups except for the -Te spectral coherence. The latter was significantly lower in patients with sustained VT than in those without ( versus , ). Although the responsible mechanism remains conjectural, the -Te spectral coherence holds promise as a noninvasive marker predicting malignant ventricular arrhythmias.