Research Article

Exploring Population Pharmacokinetic Modeling with Resampling Visualization

Figure 3

Plots to examine the resampling designs (a) for case deletion and (b) bootstrap. In each case the run ID is plotted horizontally, and the vertical axis displays which cases were in or out of the sample. For the case deletion design we plot the ID number of the subject deleted for the run. Lines connect sequential runs. If the deletion was done sequentially by PsN, then we would see a straight line from (1, 1) to (100, 100). This is not the case: in the first run, the first patient was deleted; in the second run, the 10th patient was deleted; and in the third run, the 100th patient was deleted.
585687.fig.003a
(a)
585687.fig.003b
(b)