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BioMed Research International
Volume 2014, Article ID 589296, 15 pages
Review Article

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

1Department of Gynecology, Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, Hunan 410013, China
2Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China

Received 30 March 2014; Revised 11 June 2014; Accepted 18 June 2014; Published 1 September 2014

Academic Editor: Justin C. Konje

Copyright © 2014 Umme Salma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The primary purpose of this paper is to assess the efficacy of the use of the intrauterine device (IUD) as an adjunctive treatment modality, for intrauterine adhesions (IUAs). All eligible literatures were identified by electronic databases including PubMed, Scopus, and Web of Science. Additional relevant articles were identified from citations in these publications. There were 28 studies included for a systematic review. Of these, 5 studies were eligible for meta-analysis and 23 for qualitative assessment only. Twenty-eight studies related to the use of IUDs as ancillary treatment following adhesiolysis were identified. Of these studies, 25 studies at least one of the following methods were carried out as ancillary treatment: Foley catheter, hyaluronic acid gel, hormonal therapy, or amnion graft in addition to the IUD. There was one study that used IUD therapy as a single ancillary treatment. In 2 studies, no adjunctive therapy was used after adhesiolysis. There was a wide range of reported menstrual and fertility outcomes which were associated with the use of IUD combined with other ancillary treatments. At present, the IUD is beneficial in patients with IUA, regardless of stage of adhesions. However, IUD needs to be combined with other ancillary treatments to obtain maximal outcomes, in particular in patients with moderate to severe IUA.