Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1/Th2 Type Immune Response and Inhibits Larval Development in the Host
Figure 1
Amino acid sequence alignment and in silico structure of Bm-iPGM. (a) Multiple sequence alignment of the deduced amino acid sequence of Bm-iPGM; Bm-iPGM sequence was aligned with Bacillus anthracis cofactor-independent 2 phosphoglycerate mutase taken as template (Accession no. 2IFY_A) using Clustal W. Bm-iPGM showed 41% identity with amino acid sequence of B. anthracis iPGM. Regions of identity (), strong similarity (:), and weak similarity (.) are displayed. (b) In silico cartoon structure of Bm-iPGM. Helical content matches with the experimental CD data. (c) Bm-iPGM in silico cartoon structure showing quantitatively predicted MHCI and MHCII binding stretches (regions in red are presented by MHCI while the dark blue are presented by MHCII).
